Imara to Discontinue P-IIb (Ardent & Forte) Trial of Tovinontrine (IMR-687) for the Treatment of Sickle Cell Disease and Beta-Thalassemia
Shots:
- The company will stop P-IIb (Ardent & Forte) trial to evaluate tovinontrine (IMR-687) in patients with SCD & beta-thalassemia with an expected plan to discontinue in Q2’22
- The discontinuation was based on the interim results of (Ardent) trial for SCD which showed no significant difference in median annualized VOC RATE in the high-dose group in the ITT population, 4 (3.6%) patients discontinued before 24wk. due to AES
- The interim results in the (Forte) trial for beta-thalassemia demonstrated no benefit in transfusion burden or improvement in disease-related biomarkers while 1 NTDT & 8 TDT patients (3.3% and 10.8%) discontinued the study due to AEs. The therapy was well-tolerated across both studies
Ref: Globe Newswire | Image: Businesswire
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